Angew.Chem.Int.Ed.2017,56,11599~11603吗啡烷(morphan,或称2-azabicyclo[3.3.1]nonane)结构一直以来是合成化学的研究热点,也是药物化学里重要的优势骨架.在著名的生物碱morphine和strychnine以及近十年来akuammiline家族系列生物碱的全合成中,该核心骨架是新方法和新策略研究的方向标.中国科学院上海有机化学研究所洪然课题组从设计新颖的反应类型入手,巧妙 Angew.Chem.Int.Ed.2017,56,11599 ~ 11603 Morphan (or 2-azabicyclo [3.3.1] nonane) structure has long been a hot spot in the field of synthetic chemistry and is also an important backbone of medicinal chemistry The core framework is the direction of new methods and strategies in the well-known alkaloids morphine and strychnine and the akammiline family of alkaloids in the past decade.Hong Ran’s group from Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Novel reaction types to start with clever