目的:对应用根治性全胃切除空肠间置代胃术对患有胃癌的患者实施治疗的临床效果进行研究。方法:选择本院收治的胃癌患者46例,随机分为对照组和观察组,每组23例。采用根治性全胃切除P型Roux-en-Y空肠间置代胃术对对照组患者实施治疗;采用根治性全胃切除功能性空肠间置代胃术对观察组患者实施治疗。对比两组患者手术治疗效果、治疗期间并发症人数、治疗前后相关营养指标的改善幅度、手术治疗的操作时间和术后住院治疗总时间。结果:对照组患者治疗总有效率为69.6%;观察组患者治疗总有效率为91.3%(P<0.05);治疗期间并发症人数明显少于对照组,组间比较,差异具有统计学意义(P<0.05);治疗前后相关营养指标的改善幅度明显大于对照组,组间比较,差异具有统计学意义(P<0.05);手术治疗的操作时间和术后住院治疗总时间明显短于对照组,组间比较,差异具有统计学意义(P<0.05)。结论:应用根治性全胃切除功能性空肠间置代胃术对胃癌患者实施治疗的临床效果明显。 OBJECTIVE: To study the clinical effect of radical gastrectomy and jejunal replacement on patients with gastric cancer. Methods: Forty-six patients with gastric cancer admitted to our hospital were randomly divided into control group and observation group, with 23 cases in each group. The patients in the control group were treated with radical gastrectomy and P-type Roux-en-Y jejunal intervertebral ventriculostomy. Patients in the observation group were treated with radical total gastrectomy and functional jejunal intervertebral replacement. The surgical treatment effect, the number of complications during treatment, the improvement of nutritional indexes before and after treatment, the operation time of surgical treatment and the total duration of postoperative hospitalization were compared between the two groups. Results: The total effective rate of the control group was 69.6%. The total effective rate of the observation group was 91.3% (P <0.05). The number of complications during the treatment period was significantly less than that of the control group. There was significant difference between the two groups P <0.05). The improvement of nutritional index before and after treatment was significantly greater than that of the control group. There was significant difference between the two groups (P <0.05). The operation time of the operation and the total postoperative hospitalization time were significantly shorter than those of the control group , The difference between groups was statistically significant (P <0.05). Conclusion: The clinical effect of radical gastrectomy and functional jejunal interposition on gastric cancer patients is obvious.