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目的探讨还原型谷胱甘肽在原发性肝癌介入治疗后的保肝作用。方法回顾性分析2010年1月—2013年6月收治的原发性肝癌患者110例,按照随机数字表法分为对照组50例和治疗组60例,均给予肝动脉化学性栓塞和灌注治疗。对照组,静脉滴注维生素C 2.0 g,维生素B6 0.2 g,肌苷2.0 g,以及支链氨基酸250 ml,每日1次,术后连续使用1周;治疗组,在前述基础用药上加用还原型谷胱甘肽1.8 g,以5%葡萄糖溶液250 ml配伍静脉滴注。同时检测术前和术后1周各项肝功能指标,进行两组间比较。结果治疗前两组肝功能、病情无明显差异。介入治疗1周后,治疗组和对照组转氨酶(ALT、AST)、总胆红素(TBIL)均明显升高(P<0.05),血清前白蛋白(PA)均明显降低(P<0.05);治疗组各项指标变化明显优于对照组(P<0.05)。结论还原型谷胱甘肽能明显改善原发性肝癌介入治疗引起的肝功能损害,有很好的临床应用价值。
Objective To investigate the hepatoprotective effects of reduced glutathione on primary hepatocellular carcinoma after interventional therapy. Methods A retrospective analysis of 110 patients with primary liver cancer who were admitted from January 2010 to June 2013 was divided into control group (n = 50) and treatment group (n = 60) according to random number table. All patients were given chemical embolization and perfusion of hepatic artery . Control group, intravenous infusion of vitamin C 2.0 g, vitamin B6 0.2 g, inosine 2.0 g, and branched-chain amino acids 250 ml once daily for 1 week after continuous use; treatment group, the above-mentioned basic drugs plus Reduced glutathione 1.8 g, with 5% glucose solution 250 ml compatibility intravenous drip. At the same time, preoperative and postoperative 1 week of various liver function indexes were measured and compared between the two groups. Results before treatment, liver function, no significant difference in disease. After intervention for one week, the levels of ALT and TBIL in the treatment group and the control group were significantly increased (P <0.05), and the serum prealbumin (PA) were significantly decreased (P <0.05) ; The treatment group indicators were significantly better than the control group (P <0.05). Conclusions Reduced glutathione can significantly improve the hepatic dysfunction induced by interventional therapy of primary liver cancer and has good clinical value.