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目的:研究湿疹喷雾剂水提醇沉纯化工艺最优条件。方法:以苦参碱含量为评价指标,采用正交设计试验法对湿疹喷雾剂的水提液醇沉工艺进行优化。结果:徐长卿、苦参醇沉最优工艺参数为:水提取液浓缩至药材∶溶剂(g∶mL)为1∶0.57,含醇量70%,醇沉时间12 h。结论:该醇沉纯化工艺合理、可行,可为湿疹喷雾剂工业化生产中药材前处理提供依据。
Objective: To study the optimal conditions for water extraction, alcohol precipitation purification of eczema sprays. Methods: With the matrine content as the evaluation index, the water extraction alcohol precipitation process of eczema spray was optimized by orthogonal design test. RESULTS: The optimal process parameters for Xu Changqing and Kushen alcohol precipitation were as follows: water extract was concentrated to medicine: solvent (g∶mL) was 1:0.57, alcohol content was 70%, and alcohol precipitation time was 12 h. Conclusion: The alcohol precipitation purification process is reasonable and feasible. It can provide the basis for the industrial treatment of eczema spray industrial production.