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目的 探讨前列地尔联合无创呼吸机对慢性阻塞性肺病(COPD)的临床疗效.方法 选取2015年1月至2016年1月在本院住院的71例COPD合并慢性呼吸衰竭患者,按照完全随机化分为前列地尔组20例(A组),无创通气组21例(B组),前列地尔联合无创通气组30例(C组),观察各组治疗后在PaO2、PaCO2、肺动脉压(mPAP)、肺功能(FEV1/FVC)方面的变化.结果 各组经过治疗后,在血气、肺动脉压、肺功能方面均有明显改善(P<0.05),且前列地尔联合无创通气组各指标明显高于其他两组(P<0.05).结论 前列地尔联合无创呼吸机在对慢性肺疾病治疗方面有良好效果.“,”Objective To observe the clinical effects of alprostadil with noninvasive positive pressure ventilation for treating chronic obstructive pulmonary disease(COPD). Methods According to the complete randomization ,71 cases of COPD patients with chronic respiratory failure that selected from January 2015 to January 2016 period in our hospital were divided to three groups,the alprostadil group,20 cases(group A),the noninvasive ventilation group,21 cases(group B),and the control group,30 cases(group C). PaO2,PaCO2,pulmonary artery pressure(mPAP)and pulmonary function(FEV1/FVC)changes were compared between groups. Results Between groups after treatment,the blood gas,pulmonary artery pressure and pulmonary function were improved significantly (P<0.05),and the control group was obviously higher than that of other two groups(P<0.05). Conclusion Alprostadil with noninvasive positive pressure ventilation has good effect in treatment of chronic lung disease.