论文部分内容阅读
目的了解青岛地区乙型肝炎病毒(HBV)基因型分布特征,探讨其与肝细胞癌的相关性。方法选取HBVDNA阳性患者共112例,其中慢性乙型肝炎(CHB)患者40例、肝硬化(LC)患者38例、肝细胞癌(HCC)患者34例,应用荧光PCR(探针)法检测HBV基因型。结果112例患者中,HBV基因型B型1例(0.9%),C型95例(84.8%),非B非C型16例(14.3%),HBV基因型B型、C型的分布频率在3组之间的差异均无统计学意义(P值均>0.05)。结论青岛地区HBV基因型以C型为主,未发现HBV基因型B型、C型与肝细胞癌的发生存在相关性。
Objective To understand the distribution of hepatitis B virus (HBV) genotypes in Qingdao and to explore its relationship with hepatocellular carcinoma. Methods One hundred and twelve patients with positive HBVDNA were enrolled in this study. Forty patients with chronic hepatitis B (CHB), 38 with cirrhosis (LC) and 34 with hepatocellular carcinoma (HCC) were enrolled in this study. Fluorescent PCR (probe) genotype. Results Among the 112 patients, HBV genotype B was found in 1 case (0.9%), in 95 cases (84.8%) in C genotype, in 16 cases (14.3%) in non-B non-C genotype and in B genotype There was no significant difference among the three groups (P> 0.05). Conclusion The genotypes of HBV in Qingdao are mainly C type. There is no correlation between HBV genotype B and C genotypes and the occurrence of HCC.