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本文对吡效隆0.1％液剂进行了小鼠经口急性毒性试验,大鼠经皮急性毒性试验,家兔一次皮肤刺激试验。家兔急性眼刺激试验。小鼠骨髓细胞微核试验及鼠伤寒沙门氏菌/微粒体系统(Ames)试验。结果急性毒性LD_(50)为6810mg/kg体重(小鼠,经口)和大于10000mg/kg体重(大鼠,经皮);皮肤粘膜刺激试验结果表明:该样品具有轻度皮肤刺激性及中度眼刺激作用;在340-3400mg/kg体重剂量范围内,其各剂量组骨髓嗜多染红细胞(WE)微核率(‰)为3.18-4.68,与阴性对照组比较无明显升高;Ames试验结果显示:在0.01-10.0ul原液/皿剂量范围内,在±S_9的条件下。选用TA_(97)、TA_(98)和TA_(100)作为试验菌株,各剂量组与阴性对照组自发回变菌落数的比值(R_t/R_c)均小于2,结果阴性。
In this paper, piperitone 0.1% liquid oral acute toxicity test in rats, rats acute dermal toxicity test, a rabbit skin irritation test. Acute eye irritation test in rabbits. Mouse bone marrow micronucleus test and Salmonella typhimurium / microsomal system (Ames) test. Results The acute toxicity LD 50 was 6810 mg / kg body weight (mouse, oral) and greater than 10000 mg / kg body weight (rat, percutaneous). The skin mucosal irritation test showed that the sample had mild skin irritation and moderate (WE) micronucleus rate (‰) of 3.18-4.68 in each dose group in the range of 340-3400mg / kg body weight, no significant increase compared with the negative control group; Ames The experimental results show that: 0.01-10.0ul stock solution / dish dose range, in the condition of ± S_9. TA_ (97), TA_ (98) and TA_ (100) were selected as test strains. The ratio of spontaneous return colony numbers (R_t / R_c) of each dose group and negative control group was less than 2, the result was negative.