本文报告用间接免疫荧光试验(IFL)测定200例病毒性肝炎患者血清抗平滑肌自身抗体(SMA)的结果。分析表明:甲型肝炎病毒(HAV)无论是单纯感染或是与乙型肝炎病毒(HBV)合并感染、患者血清SMA的阳性率均较HBV感染时高(P<0.005),而且与HBV复制受抑制相关。HAV感染后可抑制HBV的复制,可能因患者血清中曾存在循环干扰素(IFN),鉴于这种HAV与HBV之间的病毒干扰现象,作者提出,定期多次应用甲肝疫苗或其它药物不断诱生IFN,有可能为乙型肝炎的治疗开辟新的途径。 This article reports the results of serum anti-smooth muscle autoantibodies (SMA) in 200 patients with viral hepatitis measured by indirect immunofluorescence assay (IFL). The results showed that the positive rate of serum SMA in patients with hepatitis A virus (HAV) infection was significantly higher than that in HBV infection (P <0.005), either alone or in combination with Hepatitis B virus (HBV) Suppression related. HAV infection can inhibit the replication of HBV may be due to the presence of circulating interferon (IFN) in the serum of patients, in view of this virus interference between HAV and HBV phenomenon, the authors suggest that several regular application of hepatitis B vaccine or other drugs continue to induce Health IFN, may open up new avenues for the treatment of hepatitis B.