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目的:探讨芪红颗粒联合依达拉奉对冠脉搭桥术后心律失常及患者氧化应激水平的影响。方法:选取2014年6月—2015年6月在我科住院的74例冠心病行冠脉搭桥术患者为研究对象,对照组患者在术后予溶栓(阿司匹林肠溶片、氯吡格雷口服),调节血脂、降压、改善冠脉微循环等药物常规治疗,并联合依达拉奉注射液。观察组在对照组基础上,自术后口服芪红颗粒,比较两组患者术后2周房性早搏、室性早搏、阵发性室上性心动过速、房扑、房颤发生例数,GSH-PX、SOD、MDA以及AOPP等应激指标及LAD、LVEDd、EF、BNP等心功能指标。结果:观察组患者发生房性早搏、室性早搏、阵发性室上性心动过速、房扑、房颤分别为12例、16例、20例、8例、9例;对照组患者发生房性早搏、室性早搏、阵发性室上性心动过速、房扑、房分别为20例、25例、27例、16例、17例;观察组房性早搏、室性早搏、阵发性室上性心动过速、房扑、房颤发生例数均比对照组低,差异有统计学意义,P<0.05。治疗后,观察组患者MDA、AOPP含量分别为(18.45±2.46)U/L、(40.61±5.31)μmol/L,明显低于对照组(26.38±2.07)U/L、(71.32±4.43)μmol/L;观察组GSH-PX、SOD含量分别为(229.28±29.17)μg/m L、(19.26±4.25)μg/m L,明显高于对照组(175.46±20.38)μg/m L、(11.36±2.47)μg/m L,差异有统计学意义。治疗后观察组与对照组LAD、LVEDd、BNP均下降,EF上升,且观察组优于对照组,差异具有统计学意义(P<0.05)。结论:芪红颗粒联合依达拉奉可以降低冠脉搭桥术后患者应激反应,降低心律失常,改善心功能。
Objective: To investigate the effect of Qihong granule combined with edaravone on cardiac arrhythmia after coronary artery bypass graft and the level of oxidative stress in patients. Methods: Totally 74 patients undergoing coronary artery bypass surgery were enrolled in our department from June 2014 to June 2015. Patients in the control group were treated with aspirin (aspirin enteric-coated tablets, clopidogrel orally ), Regulate blood lipids, blood pressure, improve the conventional treatment of coronary microcirculation and other drugs, and combined edaravone injection. On the basis of the control group, the observation group was given Qihuang granules orally after operation, and the number of cases of atrial premature beats, premature ventricular contractions, paroxysmal supraventricular tachycardia, atrial flutter and atrial fibrillation were compared between the two groups , GSH-PX, SOD, MDA and AOPP and other cardiac function indexes such as LAD, LVEDd, EF and BNP. Results: The incidence of atrial premature beats, premature ventricular contractions, paroxysmal supraventricular tachycardia, atrial flutter and atrial fibrillation in the observation group were 12 cases, 16 cases, 20 cases, 8 cases and 9 cases respectively. The control group patients Atrial premature beats, premature ventricular contractions, paroxysmal supraventricular tachycardia, atrial flutter, room were 20 cases, 25 cases, 27 cases, 16 cases, 17 cases; observation group atrial premature beats, premature ventricular contractions, The number of cases of paroxysmal supraventricular tachycardia, atrial flutter and atrial fibrillation were lower than the control group, the difference was statistically significant, P <0.05. After treatment, the levels of MDA and AOPP in the observation group were (18.45 ± 2.46) U / L and (40.61 ± 5.31) μmol / L, respectively, which were significantly lower than those in the control group (26.38 ± 2.07 U / L and 71.32 ± 4.43 μmol / L; The levels of GSH-PX and SOD in the observation group were (229.28 ± 29.17) μg / m L and (19.26 ± 4.25) μg / m L, respectively, which were significantly higher than those in the control group (175.46 ± 20.38) μg / ± 2.47) μg / m L, the difference was statistically significant. After treatment, the LAD, LVEDd and BNP in observation group and control group decreased, EF increased, and the observation group was superior to the control group, the difference was statistically significant (P <0.05). Conclusion: Qihong granule combined with edaravone can reduce stress response in patients after coronary artery bypass grafting, reduce arrhythmia and improve cardiac function.