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采用毛细管气相色谱 -电子捕获法测定 12名健康男性受试者单剂量舌下交叉喷服国产和进口硝酸异山梨酯气雾剂 5 mg后的血药浓度。结果两者的 k分别为 0 .872、0 .73 6h- 1 ,Tmax为 0 .2 4 3、0 .2 0 8h,Cmax为 4 .5 2 1、4 .62 8μg/L。国产气雾剂的相对生物利用度为 95 .3 5 %。
Plasma concentrations of 5 mg domestic and imported isosorbide dinitrate aerosol spray were measured by capillary gas chromatography-electron capture method in 12 healthy male volunteers with single sublingual crossover injection. Results k of the two were 0. 872,0. 73 6h-1, Tmax was 0.243,0. 208h, Cmax was 4. 5 2 1,4. 62 8μg / L. The relative bioavailability of domestic aerosols was 95.35%.