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为探讨层粘连蛋白 (LM)及纤维粘连蛋白 (FN)在米非司酮药物流产 (以下简称药流 )后子宫持续出血时的表达 ,对 2 0例米非司酮 +米索前列醇药物流产后子宫出血 (出血组 )的刮出组织及 1 0例人工流产负压吸宫术吸出的组织 (对照组 ) ,用HE及免疫组织化学方法染色并观察标本。结果 :出血组的刮出组织中 4 5%可见滋养细胞或绒毛 ,90 %发现蜕膜组织。 2组蜕膜组织的血管及腺上皮基膜、蜕膜细胞周围和一部分蜕膜细胞胞质内都含有较丰富的LM与FN ,并且 2组间比较 ,FN与LM含量表达无明显差异 (P >0 .0 5)。说明残留蜕膜中含有能分泌大量LM与FN的蜕膜细胞和血管 ,致使蜕膜组织与子宫壁牢固地结合而不易脱落 ,影响内膜发育而引起出血。
To investigate the expression of laminin (LM) and fibronectin (FN) during continuous uterine bleeding after mifepristone abortion (hereinafter referred to as drug abortion), 20 cases of mifepristone plus misoprostol medical abortion (Bleeding group) and 10 cases of induced abortion aspiration (as control group). The cells were stained with HE and immunohistochemistry to observe the specimens. Results: Twenty-five to five percent of the scraped tissues in the bleeding group showed trophoblastic or villous hair, and decidual tissue was found in 90%. There were abundant LM and FN in the blood vessels of the decidua and glandular epithelial basement membrane, and around the decidual cells and part of the decidual cell cytoplasm. There was no significant difference between the two groups in the expression of FN and LM (P > 0 .0 5). Explain the residual decidual contains can secrete a large number of LM and FN decidual cells and blood vessels, resulting in decidua firmly combined with the uterine wall is not easy to fall off, affecting the development of the intima caused by bleeding.