论文部分内容阅读
目的对云南省近10a儿童川崎病(KD)发病情况进行流行病学调查,分析云南省川崎病发病、分布、流行特征及临床预后。方法采用日本-中国KD流行病学调查表对云南省136家设有儿科的县级以上医院,于1997年1月1日-2006年12月31日10a间住院的川崎病患儿进行填表调查。每5年进行1次,共进行2次。结果反馈调查信息共130家,调查表回收率95.6%,15个地区47家医院共报告KD患儿1662例;云南省儿童KD发病率1997年为0.351/万,而2006年达1.36/万,平均0.651/万;男女比为1.58:1.0;发病年龄2个月～14岁,5岁以下患儿占74.19%;患儿多集中于城市,但农村患儿有增加趋势;共11个少数民族,其患儿占6.4%;全年均可发病,无明显高峰季节;临床症状以发热5d以上最为常见;急性期冠状动脉改变为20.64%,其中冠状动脉扩张占冠状动脉改变的82.5%,冠状动脉瘤占17.5%,急性期无死亡病例,再发率为0.36%。结论云南省KD发病率呈增高趋势;在省内有明显的区域分布,高寒地区无病例报道;发病年龄5岁以下儿童居多,性别分布和冠状动脉损害与国内部分省市相近;KD冠状动脉病变已是儿童后天性心脏病的主要病因之一,急性期早期诊断治疗是避免发生后遗症的重要措施。
Objective To investigate the prevalence of Kawasaki disease (KD) in nearly 10 years in Yunnan province and analyze the incidence, distribution, epidemiology and clinical prognosis of Kawasaki disease in Yunnan province. Methods A total of 136 children with Kawasaki disease who were admitted to hospitals in Yunnan Province from January 1 to December 31, 2006 were enrolled in this study using the Japan-China KD epidemiological questionnaire. survey. Once every 5 years, a total of 2 times. Results A total of 130 feedback survey information was collected and the response rate was 95.6%. A total of 1662 children with KD were reported from 47 hospitals in 15 regions. The incidence of KD in Yunnan Province was 0.351 / million in 1997, reaching 1.36 / An average of 0.651 / million; male to female ratio was 1.58: 1.0; age of onset of 2 months to 14 years, 74.19% of children under 5 years of age; children with more concentrated in the city, but children in rural areas have an increasing trend; a total of 11 ethnic minorities , Which accounted for 6.4% of all cases; all-year disease could be observed without significant peak season; the most common clinical symptoms were fever more than 5 days; acute coronary artery changes were 20.64%, of which coronary artery dilation accounted for 82.5% of coronary artery changes. Aneurysms accounted for 17.5%, no deaths in acute cases, the recurrence rate was 0.36%. Conclusions The incidence of KD in Yunnan Province shows an increasing trend. There is a clear regional distribution in the province and no cases are reported in the alpine region. The children younger than 5 years of age at onset are mostly affected by gender and coronary artery lesions. KD coronary artery lesions Is one of the major causes of acquired heart disease in children, early diagnosis and treatment of acute phase is an important measure to avoid the occurrence of sequelae.