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目的评价酮咯酸氨丁三醇联合丙泊酚静脉麻醉用于人工流产术的临床效果及安全性。方法选择120例自愿实施无痛人工流产术患者,随机分为两组,A组仅使用丙泊酚,B组先静脉滴注酮咯酸氨丁三醇30mg、5min后静脉推注丙泊酚。监测两组患者在不同时间点的的平均动脉压(MAP)、心率(HR)、呼吸(RR)及血氧饱和度(SpO2),比较两组患者的丙泊酚用量、手术时间、术中肢动、清醒时间、疼痛评分。结果所有患者均顺利完成手术,两组术中的MAP、HR均较术前显著降低(P<0.05),但组间差异无统计学意义(P>0.05)。B组的丙泊酚用量、清醒时间、疼痛评分、麻醉效果显著优于A组(P<0.05)。两组手术时间无显著性差异(P>0.05)。结论在无痛人流术中辅助应用酮咯酸氨丁三醇能增强麻醉效果,不增加由于循环抑制所带来的风险,患者清醒更快,术后下腹痛减少,安全、有效,值得临床推广应用。
Objective To evaluate the clinical efficacy and safety of ketorolac tromethamine combined with propofol intravenous anesthesia for artificial abortion. Methods A total of 120 patients who underwent painless artificial abortion were randomly divided into two groups. Group A received propofol only. Group B received intravenous ketorolac tromethamine 30 mg. Propofol . The mean arterial pressure (MAP), heart rate (HR), respiration (RR) and oxygen saturation (SpO2) of the two groups were monitored at different time points. Propofol consumption, operation time, Limb movements, awake time, pain score. Results All the patients underwent successful operation. MAP and HR in both groups were significantly lower than those before operation (P <0.05), but there was no significant difference between the two groups (P> 0.05). Propofol dosage, awake time, pain score and anesthesia in group B were significantly better than those in group A (P <0.05). There was no significant difference between the two groups in operation time (P> 0.05). Conclusions The adjunctive use of ketorolac tromethamine in painless abortion can enhance the anesthetic effect without increasing the risk due to the inhibition of circulation. Patients are awake faster and have less postoperative abdominal pain reduction, which is safe and effective and worthy of clinical promotion application.