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目的 探讨病灶大小 ,浸润深度 ,对女性生殖器恶性黑色素瘤预后的影响。方法 对辽宁省肿瘤医院1 979年 1 0月至 2 0 0 2年 5月收治的 1 3例女性生殖器恶性黑色素瘤临床资料进行回顾性分析。结果 1 3例中 1例病期晚 ,无法做根治性切除术 ,仅腹壁下动脉插管行区域灌注化疗及免疫治疗。 1 2例接受手术治疗 ,治疗后总的 5年存活率为 2 3 0 %。其中病灶≤ 2cm 7例 ,平均生存期 6 2 3个月 ;病灶 >2cm 5例 ,平均生存期 31 8个月。病灶浸润深度 0 76～ <1 5 0mm 2例 ,平均生存期 84 5个月 ;浸润深度 1 5～ <4 0mm 3例 ,平均生存期 6 8 7个月 ;浸润深度≥ 4 0mm 7例 ,平均生存期 31 4个月。结论 女性生殖器恶性黑色素瘤预后差 ,但早期确诊并采用以手术为主 ,以化疗和免疫治疗为辅的综合治疗 ,能改善预后及延长生存时间。
Objective To investigate the effect of lesion size and depth of invasion on the prognosis of female genital malignant melanoma. Methods The clinical data of 13 cases of female genital malignant melanoma admitted to Liaoning Cancer Hospital from January 1979 to May 2002 were retrospectively analyzed. Results 1 case of 1 case late, can not be a radical resection, only the inferior abdominal artery catheterization regional perfusion chemotherapy and immunotherapy. Twelve patients underwent surgery, with a total 5-year survival rate of 230% after treatment. The lesions ≤ 2cm 7 cases, the average survival period 6 2 3 months; lesions> 2cm 5 cases, the average survival of 31 8 months. The depth of invasion was 0 76 ~ <150 mm. The average survival time was 84 5 months. The depth of invasion was 15 ~ 40 mm. The average survival time was 688 months. The depth of invasion was ≥ 40 mm. The mean Survival of 31 4 months. Conclusion The prognosis of female genital malignant melanoma is poor. However, the early diagnosis and the use of combined surgery with chemotherapy and immunotherapy supplemented by chemotherapy and prognosis can improve the prognosis and extend the survival time.