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目的:探讨急性白血病(AL)血小板输注无效的原因。方法:观察106例AL患者的263例次单采血小板输注效果并检测血小板抗体,分析讨论血小板无效输注的影响因素。结果:①AL血小板无效输注率为43.35%;②血小板抗体阳性检出率为32.32%;③血小板输注有效组与无效组的抗体阳性检出率的差异有统计学意义(P<0.01)。④AL发热组输注无效率高于未发热组(P<0.01);脾脏肿大与无肿大组无效输注率差异有统计学意义(P<0.01)。结论:引起血小板输注无效的病因复杂。血小板输注前应进行血小板抗体的筛选,避免或减少造成血小板输注无效的原因,提高血小板输注的有效率。
Objective: To investigate the causes of ineffective platelet transfusion in acute leukemia (AL). Methods: Totally 263 cases of single platelet transfusion in 106 patients with AL were observed and the platelet antibodies were detected. The influencing factors of platelet invalid infusion were analyzed. Results: ① The rate of invalid platelet transfusion was 43.35%; ② The positive rate of platelet antibody was 32.32%; ③ The positive rate of antibody positive between platelet transfusion group and non-effective group was statistically significant (P <0.01). (4) The inefficiency of infusion in AL fever group was higher than that in non-fever group (P <0.01). The difference of invalid infusion rate between spleen enlargement and no enlargement group was statistically significant (P <0.01). Conclusion: The causes of ineffective platelet transfusion are complex. Pre-platelet transfusion platelet antibody screening should be conducted to avoid or reduce the causes of ineffective platelet transfusions and increase the efficiency of platelet transfusion.