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本文报导8例骨髓纤维化,其中6例继发于慢性白血病,2例为原发性。男女各4例,年龄范围为23—67岁。1例原发性骨纤有苯接触史20余年,余7例均无明显毒物接触史。起病至确诊时间最短2个月,最长6年,8例病人血片中可见幼稚粒、红细胞及异形红细胞,骨髓象示:6例增生低下,2例增生活跃。8例经骨髓活检针病理证实纤维组织增生。1例急性骨纤死于感染,7例经用雄激素、强的松及输血等治疗,病情均有不同程度的改善而出院。
This article reports 8 cases of myelofibrosis, of which 6 cases of secondary to chronic leukemia, 2 cases of primary. 4 men and women in each case, the age range of 23-67 years old. One case of primary bone fiber benzene exposure history of more than 20 years, more than 7 cases were no obvious exposure history. From the onset to the diagnosis of the shortest 2 months, up to 6 years, 8 cases of patients visible in the blood tablets of immature granulocytes, red blood cells and irregular red blood cells, bone marrow showed: 6 cases of hyperplasia, 2 cases of hyperplasia. 8 cases of bone marrow biopsy needle pathology confirmed fibrosis. One case of acute fibrosis died of infection, and 7 cases were treated with androgen, prednisone and blood transfusions. All patients were discharged with different degrees of improvement.