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膜剂(Milms)具有贴附粘膜上的特点,且能通过动力学渗透,使药物达到局部浓度高而起到增长和延长疗效,促进溃疡愈合的作用,是一种腔道粘膜局部用药的理想剂型。为此,我们研制了以厚朴为主药的口腔膜剂。在研制过程中,我们利用正交设计筛选出最佳处方用量。同时,我们用薄层—紫外分光光度法对本膜剂中的主要有效成分厚朴酚(Magnolol)及和厚朴酚(Honokiol)进行了定性、定量分析。
The film has the characteristics of adhesion on the mucous membrane, and can penetrate through the dynamics, so that the medicine can reach a local high concentration to increase and prolong the curative effect and promote the healing of the ulcer. It is an ideal medicine for local administration of mucosal mucosa. Formulations. For this purpose, we developed an oral film based on honokiol. In the development process, we used orthogonal design to screen out the best prescription dosage. At the same time, we used thin layer-ultraviolet spectrophotometry to qualitatively and quantitatively analyze Magnolol and Honokiol, the main active ingredients in the film.