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目的了解医院2007年12月-2008年12月重症监护病房铜绿假单胞菌的耐药情况,给临床治疗提供参考。方法收集重症监护病房分离的404株铜绿假单胞菌,培养鉴定,采用纸片扩散法(K-B法)测定其对15种抗菌药物的敏感性。结果耐药率最高为复方新诺明(97.7%),其次为哌拉西林(82.4%).耐药率较低的有多粘菌素B(6.7%)、头孢吡肟(16.2%)、头孢他啶(28%),阿米卡星(22.4%),头孢哌酮/舒巴坦(21.1%),亚胺培南(15.0%)美罗培南(14.0%)等.结论铜绿假单胞菌是目前临床上较为常见的革兰阴性杆菌,治疗上可联合应用头孢哌酮/舒巴坦与阿米卡星,在此基础上还可加用头孢他啶,以提高治疗效果。
Objective To understand the resistance of Pseudomonas aeruginosa in the ICU from December 2007 to December 2008 and to provide reference for clinical treatment. Methods 404 strains of Pseudomonas aeruginosa isolated from intensive care unit were collected and identified. The sensitivity to 15 antimicrobial agents was determined by disk diffusion method (K-B method). Results The highest drug resistance rate was compound sulfamethoxazole (97.7%), followed by piperacillin (82.4%), and the lowest drug resistance rates were polymyxin B (6.7%), cefepime (16.2%), Ceftazidime (28%), amikacin (22.4%), cefoperazone / sulbactam (21.1%), imipenem (15.0%) meropenem (14.0%), etc. Conclusion Pseudomonas aeruginosa is Gram-negative bacteria currently more common clinical treatment of cefoperazone / sulbactam and amikacin can be combined on the basis of ceftazidime can be added to improve the therapeutic effect.