探讨降钙素基因相关肽 (CGRP)和P物质 (SP)在SD大鼠扣带束及周围皮质 (CB/CT)对伤害性刺激反应的作用。应用热板和机械压力实验法 ,以大鼠后爪缩爪反应潜伏期 (HWL)为痛阈指标 ,观察CB/CT微量注射CGRP或SP后的HWL的变化。CB/CT内注射 0 .12 5 ,0 .2 5 ,0 .5nmolCGRP或SP均显著地降低大鼠对热板的双侧HWL ,且呈量效关系 ;0 .12 5nmolCGRP或 0 .5nmolSP能显著降低大鼠对机械压力的HWL。CB/CT微量注射CGRP或SP使大鼠对热板和机械压力刺激发生痛敏。 To investigate the effects of calcitonin gene related peptide (CGRP) and substance P (SP) on noxious stimulation in cingulate cortex and peripheral cortex of SD rats. The changes of HWL after CB / CT microinjection of CGRP or SP were observed using hot plate and mechanical stress test. CB / CT intracerebral injection of 0.12 5, 0 .2 5, 0 .5nmolCGRP or SP significantly reduced bilateral HWL on the hot plate in rats, and the dose-response relationship; 0.125nmCGRP or 0.05nmolSP can significantly Reduces rat’s HWL on mechanical stress. Microinjection of CGRP or SP into CB / CT sensitized rats to hot plate and mechanical stress stimulation.