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目的 探讨血内皮素 (ET)和一氧化氮 (NO)在毛细支气管炎 (毛支 )和婴幼儿哮喘 (哮喘 )中的变化及意义。 方法 用放射免疫分析法和分光光度比色法分别检测毛支、哮喘患儿急性期和缓解期血ET和NO ,并与正常儿童进行比较。 结果 血浆ET在毛支组和哮喘组 ,急性期均明显高于正常组 (P均 <0 0 1) ,缓解期均下降 ,与正常组比较无显著差别 (P均 >0 0 5 ) ;两组急性期比较无差别 (P >0 0 5 )。与血浆ET一样 ,血清NO在毛支组和哮喘组 ,急性期均显著高于正常组 (P <0 0 1和P <0 0 5 ) ;缓解期则下降 ,与对照组比无显著差别 ,(P均 >0 0 5 ) ;两组急性期相比 ,差异无显著性 (P >0 0 5 )。两组急性期血浆ET与血清NO呈明显正相关 (P <0 0 5 )。 结论 在毛支和哮喘中 ,血ET和NO均升高 ,二者关系密切 ,均可能参与毛支及哮喘的发病
Objective To investigate the changes and significance of endothelin (ET) and nitric oxide (NO) in bronchiolitis (bronchiolitis) and infant asthma (asthma). Methods Radioimmunoassay and spectrophotometry were used to detect the levels of ET and NO in blood and asthmatic children during acute and remission respectively and compared with normal children. Results Plasma ET was significantly higher in the bronchiolitis group and the asthma group than in the normal group (P <0.01), and both in the remission stage and in the acute phase were not significantly different from those in the normal group (P> 0.05) There was no difference in acute stage (P> 0.05). As with plasma ET, serum NO was significantly higher in the bronchiolitis group and asthma group than in the normal group (P <0.01 and P <0.05), while in the remission phase, NO was not significantly different from that in the control group (P> 0.05). There was no significant difference between the two groups in acute phase (P> 0.05). There was a significant positive correlation between plasma ET and serum NO in both acute phases (P <0.05). Conclusions Both ET and NO in blood and bronchial asthma are increased, which may be involved in the pathogenesis of bronchiolitis and asthma