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目的:观察保妇康栓对人乳头瘤病毒(HPV)不同亚型感染的治疗效果。方法:将132例患者随机分为2组,观察组67例运用流式荧光杂交法进行HPV分型检测,并采用保妇康栓阴道给药治疗21天;对照组65例仅进行HPV分型检测,不给予治疗干预。比较2组用药后HPV各亚型的转归情况。结果:观察组HPV亚型总检出92例次(含双重感染和多重感染),转阴亚型数47例次,转阴率为51.09%;对照组HPV亚型总检出86例次,转阴亚型数23例次,转阴率为26.74%。2组转阴率比较,差异有显著性意义(P<0.01)。在检出的5种常见HPV亚型中,检出频率最高的52亚型2组间转阴率比较,差异无显著性意义(P>0.05);而16亚型和58亚型2组间转阴率比较,差异均有显著性意义(P<0.05)。结论:保妇康栓能有效提高HPV16亚型和58亚型的转阴率,但HPV 52亚型对保妇康栓不敏感。作用机理可能与HPV L区主要衣壳蛋白核酸序列的不同有关。
Objective: To observe the therapeutic effect of Baofukang suppository on different subtypes of human papillomavirus (HPV) infection. Methods: 132 patients were randomly divided into two groups. In the observation group, 67 cases were detected by flow cytometry (FCM) for HPV genotyping and vaginal administration with Baofukang Suppository for 21 days. In the control group, only 65 cases were genotyped for HPV Test, do not give treatment intervention. After comparing the two groups of HPV subtypes after the outcome of the situation. Results: The total number of HPV subtypes in the observation group was 92 cases (including double infection and multiple infection), the number of negative subtypes was 47 cases, and the negative conversion rate was 51.09%. In the control group, the HPV subtypes were detected 86 times in total, Negative subtype of 23 cases, negative conversion rate was 26.74%. There was a significant difference between the two groups (P <0.01). Among the five common HPV subtypes detected, there was no significant difference in the negative conversion rate between the two subtypes of 52 subtypes with the highest detection frequency (P> 0.05). However, there was no significant difference between the two subtypes of subtype 16 and subtype 58 Compared with the negative rate, the difference was significant (P <0.05). Conclusion: Baofukang suppository can effectively improve the HPV16 subtype and 58 subtype of the negative rate, but the HPV subtype 52 is not sensitive to Baofukang bolt. Mechanism of action may be related to HPV L major capsid protein nucleic acid sequence differences.