雌激素代谢物的作用雌激素体内经氧化代谢可以形成羟基代谢物,如2-羟雌二醇、4-羟雌二醇。其代谢物对儿茶酚胺氧位甲基转移酶的竞争性抑制作用能增强儿茶酚胺的活性,参与神经内分泌调节,从而对血压产生影响。雌激素还通过增加冠状动脉的β肾上腺素刺激物的敏感性调控血管的自律调节,促进心脏末梢释放β肾上腺素介质,上调β肾上腺素受体表达,使血管舒张。影响肾素血管紧张素系统肾素血管紧张素系统(RAS)对血压起着重要的调 The role of estrogen metabolites Estrogen metabolism in vivo can form hydroxyl metabolites, such as 2-hydroxy-estradiol, 4-hydroxy-estradiol. The competitive inhibition of its metabolites on catecholamine oxygen methyltransferase enhances the activity of catecholamines, and is involved in the regulation of neuroendocrine, which has an impact on blood pressure. Estrogen also regulates the regulation of blood vessels by increasing the sensitivity of the beta adrenergic stimuli in the coronary arteries, promotes the release of beta adrenergic mediators at the distal end of the heart, upregulates beta adrenergic receptor expression, and vasodilates. Impact Renin Angiotensin System The renin-angiotensin system (RAS) plays an important role in blood pressure