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目的探讨ＣＤ４４在原发性肝细胞癌中的表达及意义。方法采用高压锅抗原修复免疫组化技术，研究８２例原发性肝癌手术标本中ＣＤ４４的表达。结果在４１％的肝癌组织上可见到ＣＤ４４的表达。ＣＤ４４的表达与原发性肝细胞癌有无门静脉瘤栓形成呈密切正相关（Ｐ＜０．０１），ＣＤ４４的表达与原发性肝细胞癌的预后无显著相关（Ｐ＞０．０５）。结论ＣＤ４４赋予肿瘤细胞侵袭转移潜能。
Objective To investigate the expression and significance of CD44 in primary hepatocellular carcinoma. Methods Immunohistochemical technique of antigen retrieval in autoclave was used to study the expression of CD44 in 82 surgical specimens of primary liver cancer. As a result, the expression of CD44 was observed in 41% of liver cancer tissues. The expression of CD44 was positively correlated with the presence or absence of portal vein thrombus formation in primary hepatocellular carcinoma (P<0.01). The expression of CD44 was not significantly associated with the prognosis of primary hepatocellular carcinoma (P>0.05). . Conclusion CD44 confers tumor cell invasion and metastasis potential.