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目的研究食管鳞癌中PTEN的表达,探讨其与临床病理参数的关系及对患者预后的判断价值。方法应用免疫组织化学S-P法检测62例食管鳞癌组织标本中PTEN的表达水平。结果(1)PTEN的表达与食管壁浸润程度、淋巴结转移情况、远处转移情况、pTNM分期、肿瘤分化程度呈负相关关系(P＜0．05)。(2)高表达组患者的术后3年生存率明显低于低表达组,组间比较有统计学意义(P＜0．01)。结论PTEN表达与反映食管鳞癌恶性度的临床病理参数呈负相关关系,是独立的预后评价因素之一。
Objective To study the expression of PTEN in esophageal squamous cell carcinoma and to explore its relationship with clinicopathological parameters and its prognostic value. Methods Immunohistochemical S-P method was used to detect the expression of PTEN in 62 cases of esophageal squamous cell carcinoma. Results (1) The expression of PTEN was negatively correlated with the degree of esophageal wall infiltration, lymph node metastasis, distant metastasis, pTNM stage and tumor differentiation (P <0.05). (2) The 3-year survival rate of patients with high expression group was significantly lower than that of low expression group (P <0.01). Conclusion The expression of PTEN is negatively correlated with the clinicopathologic parameters reflecting the malignant degree of esophageal squamous cell carcinoma, which is one of the independent prognostic factors.