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[目的]探讨mi RNA-214在乳腺癌组织中的表达及其与临床病理特征及预后的关系。[方法 ]应用实时定量q PCR检测45例乳腺癌及癌旁正常组织中mi RNA-214的含量,分析其与临床病理特征、预后的关系。[结果]乳腺癌组织中mi RNA-214的含量明显低于癌旁正常组织,差异有统计学意义(P<0.01);mi RNA-214在Ki-67阴性组的表达量明显高于Ki-67阳性组,差异具有统计学意义(P=0.01);mi RNA-214水平与患者的年龄、月经状况、临床分期、肿瘤大小、淋巴结转移、ER、PR、Her-2及p53的表达均无关(P>0.05)。[结论]mi RNA-214在乳腺癌组织中呈低表达,并与Ki-67表达相关,提示其可能与乳腺癌的发生、发展及预后有关。
[Objective] To investigate the expression of miRNA-214 in breast cancer and its relationship with clinicopathological features and prognosis. [Method] The real-time quantitative q-PCR was used to detect the content of miRNA-214 in 45 cases of breast cancer and adjacent normal tissues, and its relationship with clinicopathological features and prognosis was analyzed. [Results] The content of mi RNA-214 in breast cancer tissues was significantly lower than that in adjacent normal tissues (P <0.01). The expression of mi RNA-214 in Ki-67 negative group was significantly higher than that in Ki- 67 positive group, the difference was statistically significant (P = 0.01); mi RNA-214 level had no correlation with age, menstrual status, clinical stage, tumor size, lymph node metastasis, ER, PR, Her-2 and p53 (P> 0.05). [Conclusion] The low expression of miRNA-214 in breast cancer and its correlation with Ki-67 expression suggest that mi RNA-214 may be related to the occurrence, development and prognosis of breast cancer.