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探讨大鼠局灶脑缺血再灌注后神经节苷脂（ＧＭ１）的保护作用及其对碱性纤维母细胞生长因子的特异性受体（ＦＧＦＲ１）表达的影响。方法采用栓线法制备大脑中动脉缺血再灌注模型。通过腹腔注射给予ＧＭ１利用免疫组化方法检测ＦＧＦＲ１表达情况，并对病理学改变进行观察研究。结果与对照组相比，缺血再灌组ＦＧＦＲ１表达明显增多（Ｐ＜０．０１），而ＧＭ１用药组与缺血再灌组相比，ＦＧＦＲ１表达也明显增多（Ｐ＜０．０１）。光镜及电镜观察发现，单纯缺血再灌组梗塞区病理变化明显重于ＧＭ１用药组。结论脑缺血后ＧＭ１具有明确的保护作用，可减轻脑组织的损伤程度，并能使ＦＧＦＲ１表达上调。ＧＭ１可能通过影响ＦＧＦＲ１表达水平而发挥其作用。
To investigate the protective effect of ganglioside (GM1) and its effect on the expression of fibroblast growth factor-specific receptor (FGFR1) after focal cerebral ischemia / reperfusion in rats. Methods The middle cerebral artery occlusion (MCAO) model of ischemia - reperfusion was established by suture method. GM1 was intraperitoneally injected to detect the expression of FGFR1 by immunohistochemistry, and the pathological changes were observed. Results Compared with the control group, the expression of FGFR1 in ischemia-reperfusion group was significantly increased (P <0.01). Compared with ischemia-reperfusion group, the expression of FGFR1 in GM1 group was significantly increased (P <0.01). Light microscopy and electron microscopy showed that ischemia-reperfusion infarction area pathological changes were significantly heavier than the GM1 treatment group. Conclusion GM1 has a definite protective effect after cerebral ischemia, which can reduce the damage of brain tissue and up-regulate the expression of FGFR1. GM1 may exert its effect by affecting the expression level of FGFR1.