众所周知,临床上氨基糖苷类抗生素往往因耐药菌的酶促修饰而失效。能够修饰氨基糖苷类的酶可分为三类:N-乙酰转移酶、O-腺苷酰转移酶和 O-磷酸转移酶。然而,只有一种修饰酶存在不一定会产生对氨基糖苷类的耐药性,这是因为修饰速率也是产生耐药性的一个重要决定因素。已知有这样一些例子,即某些细菌含有能够修饰某种氨基 As we all know, clinically aminoglycoside antibiotics often due to resistant bacteria enzyme modification fails. Enzymes capable of modifying aminoglycosides fall into three categories: N-acetyltransferase, O-adenylyltransferase and O-phosphotransferase. However, the presence of only one modified enzyme does not necessarily result in resistance to aminoglycosides, since the rate of modification is also an important determinant of drug resistance. Some examples are known in which certain bacteria contain amino acids that can be modified