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目前阿尔茨海默病（ AD）已成为威胁老年人身心健康的主要疾病，但该病的发病机制仍未完全明确，治疗手段也十分有限，其主要原因之一是目前缺乏理想的AD动物模型。目前 AD动物模型主要分为β淀粉样蛋白沉积型、衰老型、脑缺血型、转基因型、链脲佐菌素型等。该文就 AD 动物模型的现状，双侧颈动脉结扎模型及环境因素模型的研究进展予以综述。“,”Alzheimer′s disease(AD) has become one of the major diseases, threatening the physical and mental health of the elderly.Unfortunately,the mechanisms behind it are still not completely uncovered,as a result of which the therapeutic options remain very limited .one of the main reasons for this embarrassing situ-ation is the lack of ideal animal models.Presently the main animal models for AD are β-amyloid peptide accumulation model,senescence-accelerated model,brain ischemia model,transgenic mice model,streptozoto-cin model and so on.Here is to make a review of the above AD models,with the emphasis on bilateral com-mon carotid artery occlusion model and environmental factors-associated model.