This paper deals with the robust stabilization and passivity of general nonlinear systems with structural uncertainty. By using Lyapunov function, it verifies that under some conditions the robust passivity implies the zero-state detectability, Furthermore, it also implies the robust stabilization for such nonlinear systems. We then establish a stabilization method for the nonlinear systems with structural uncertainty. The smooth state feedback law can be constructed with the solution of an equation. Finally, it is worth noting that the main contribution of the paper establishes the relation between robust passivity and feedback stabilization for the general nonlinear systems with structural uncertainty. The simulation shows the effectiveness of the method.