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目的 :观察胸腔内注入尿激酶 (UK)和链激酶 (SK)的方法治疗结核性多分隔性胸腔积液的疗效及对患者肺功能的改善。方法 :入院正规治疗的 30例结核性渗出性胸膜炎患者 ,治疗中经B超证实胸液呈多分隔或蜂窝状。继续尽量抽净胸水 ,随机选 2 0例用 2 5万u尿激酶 /链激酶 +生理盐水 2 0～ 5 0ml/次注入胸腔 ,每日或隔日 1次 ,连续 1～ 3次。另外 10例常规治疗作对照组。治疗前后观察 2组肺功能变化和动脉血气变化。结果 :治疗组较对照组的胸液引流更彻底 ,胸膜肥厚粘连较轻 ,肺功能获得更明显的改善 (P <0 .0 1)。结论 :胸腔内注射尿激酶或链激酶治疗非癌性尤其结核性多分隔性胸腔积液是一疗效肯定、简单、安全的方法 ,较传统的治疗方法能明显改善患者的肺功能。值得推广应用。
Objective: To observe the curative effect of tuberculous multi-sectoral pleural effusion and the improvement of lung function in patients with thoracic cavity by injecting urokinase (UK) and streptokinase (SK). Methods: 30 cases of regular treatment of tuberculosis in patients with tuberculous exudative pleurisy, the treatment proved by ultrasonography B pleural fluid was divided or honeycomb. Continue to draw the pleural effusion as much as possible, randomly selected 20 cases with 25 000 urokinase / streptokinase + saline 20 ~ 50ml / injection into the chest, daily or every other day, 1 to 3 times. Another 10 cases of conventional treatment for the control group. Before and after treatment, the changes of pulmonary function and arterial blood gas were observed in two groups. Results: The treatment group than the control group more thorough drainage of pleural fluid, pleural thick adhesions lighter, lung function was significantly improved (P <0. Conclusion: Intrathoracic injection of urokinase or streptokinase for the treatment of non-cancerous, especially tuberculous, pleural effusion is a positive, simple and safe method. Compared with the traditional treatment, it can significantly improve the lung function of patients. Worth promoting application.