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目的:观察晚期(ⅢB/Ⅳ期)非小细胞肺癌(NSCLC)患者的中医证型特点和分布规律。方法:采取回顾性调查方式,对纳入121例ⅢB/Ⅳ期NSCLC的病例进行资料采集,数据输入数据库,中医辨证分型参照《肿瘤中医诊疗指南》,由3人以上经验丰富的住院及主治医师进行辨证分型,最后由科室主任审核并确定。结果:121例ⅢB/Ⅳ期NSCLC中医证型以脾虚痰湿型最多见,占52.1%(63/121),与其他中医证型相比较有显著差异(P<0.05)。分层分析:ⅢB期、IV期(M1a)期NSCLC中脾虚痰湿型分别占50.0%(14/28)、57.1%(20/35),均与其他中医证型相比较有显著差异(P<0.05);IV期(M1b)期NSCLC中以脾虚痰湿、气阴两虚型为主,分别占50.0%(29/58)、29.3%(17/58),脾虚痰湿型与其他中医证型相比较有显著差异(P<0.05)。结论:晚期(ⅢB/Ⅳ期)NSCLC的中医证型以脾虚湿瘀为主。
Objective: To observe the characteristics and distribution of TCM syndromes in patients with advanced stage ⅢB / Ⅳ non-small cell lung cancer (NSCLC). Methods: A retrospective survey was conducted to collect data from 121 cases with stage ⅢB / Ⅳ NSCLC. The data were input into the database. According to the Guide to Diagnosis and Treatment of Tumor by TCM, the patients with more than 3 experienced inpatients and attending physicians For syndrome differentiation, and finally reviewed and identified by the department director. Results: The 121 TCM syndromes of type ⅢB / Ⅳ NSCLC were the most common type of phlegm - dampness syndrome of spleen deficiency, accounting for 52.1% (63/121), which was significantly different from other TCM syndromes (P <0.05). Hierarchical analysis: Fifty-one percent (14/28) and 57.1% (20/35) of spleen-deficiency and phlegm-dampness syndromes in stages ⅢB and M1a stage NSCLC were significantly different from other TCM syndromes (P <0.05). In Stage IV (M1b) NSCLC, there were 50.0% (29/58), 29.3% (17/58) patients with phlegm-dampness of the spleen, Syndromes were significantly different (P <0.05). Conclusion: The TCM syndromes of late stage (ⅢB / Ⅳ) NSCLC are characterized by spleen deficiency and dampness.