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动物实验证实,胚胎期缺碘或甲状腺功能不足可造成中枢神经系统发育滞缓。而长期缺碘能否造成发育成熟的中枢神经系统的损害,却很少有实验研究报道。为此,本实验以低碘饮食饲养成年大鼠使其长期缺碘后,用运动防御条件反射、脑电图和脑的形态改变为指标,来探讨缺碘对发育成熟的中枢神经系统功能和形态的影响。 54只Wistar成年大鼠分为两组:30只饲低碘饮食为缺碘组;24只饲充分供碘饮食为对照组。在实验的0、17、35、97天时分别抽两组部份大鼠检查甲状腺形态和血清T_4值。实
Animal experiments confirmed that lack of iodine or embryonic hypothyroidism can cause central nervous system development stagnation. Long-term iodine deficiency can cause the development of mature central nervous system damage, but few experimental studies have reported. To this end, the experiment with low iodine diet adult rats to long-term iodine deficiency, exercise defensive reflex, EEG and brain morphological changes as an indicator to explore the lack of iodine on the development of mature central nervous system function and The impact of morphology. Fifty-four Wistar adult rats were divided into two groups: 30 low iodine diet for iodine deficiency group; 24 full iodine diet for the control group. At 0, 17, 35, and 97 days of the experiment, two groups of rats were drawn to examine thyroid morphology and serum T_4 values respectively. real