众所周知,抗精神病药阻断了多巴胺(DA2)受体,虽然未证实这与抗精神病药效果一定有因果关系,但两者之间的关系不容否认。已证实DA2受体占有率与抗精神病效果存在阈值关系,为60%或70%。当占有率超过80%时,锥体外系副作用(EPS)发生率明显上升;而且催乳素水平的升高也可能与DA2受体 It is well-known that antipsychotics block the dopamine (DA2) receptor, and although it has not been shown to be causally related to the antipsychotic effect, the relationship between the two can not be denied. It has been demonstrated that there is a threshold relationship between DA2 receptor occupancy and antipsychotic effect of 60% or 70%. When the share of more than 80%, the incidence of extrapyramidal side effects (EPS) increased significantly; and elevated prolactin levels may also be associated with the DA2 receptor