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创伤的立即效应诸如骨折、失血是明显的、机械性的,然而它也引起了生化学家的兴趣。因为第一,创伤导致蛋白质丢失和肌肉萎缩,影响康复和生存;第二,创伤的适当治疗需要生化变化的知识;第三,意外事故性创伤提供了研究人类应激反应的机会。本文将集中讨论意外事故性创伤(不合并烧伤和脓毒症)后,蛋白质丢失的原因及其影响因素。受伤后短时期内(24小时),体温及能量产生(指氧化过程——译者)皆下降,体内能源物质尤其是葡萄糖和脂肪酸被动员。这段时期内可能趋向死亡。幸存者中,随之而发生的是体内代谢加速和蛋白质丢失的增加,以后转变为
Immediate effects of trauma such as fractures, blood loss are obvious, mechanical, however it also attracted the interest of biochemists. First, trauma leads to protein loss and muscle atrophy, affecting rehabilitation and survival. Second, proper treatment of trauma requires knowledge of biochemical changes. Third, accidental trauma offers the opportunity to study human stress responses. This article will focus on the causes of accidental trauma (not associated with burn and sepsis), the causes of protein loss and its influencing factors. Shortly after injury (24 hours), body temperature and energy production (both the oxidizer and the translator) decreased, and energy substances in the body, especially glucose and fatty acids, were mobilized. There may be a tendency to die during this period. Among the survivors, what followed was an acceleration of metabolism in the body and an increase in protein loss, which later changed to