肝脏疾病所致的神经系统损害国外报道很多,如肝性脑病、肝豆状核变性、肝性脊髓病等,但肝脏疾病导致肌萎缩侧索硬化尚未见报道。病例;李××,女,43岁。主诉:进行性肢体无力1年。5年前发现“肝功”不正常,诊断为“慢性肝炎”。1987年3月出现四肢无力,下肢显著,自诉嗜睡,头晕。症状进行性加重,至12月份四肢活动困难,不能行走,肢体萎缩明显;曾做脑电图、B Nervous system damage caused by liver disease is widely reported abroad, such as hepatic encephalopathy, hepatolenticular degeneration, hepatic myelopathy and so on, but liver disease leads to amyotrophic lateral sclerosis has not been reported. Case; Li × ×, female, 43 years old. Chief Complaint: Progressive limb weakness for 1 year. 5 years ago found that “liver function” is not normal, diagnosed as “chronic hepatitis.” In 1987 March there limb weakness, lower limbs significant, private prosecution drowsiness, dizziness. Symptoms progressive aggravating, limb activity in December is difficult, can not walk, limb atrophy; have EEG, B