以4-硝基苯乙酮为原料,经溴化、还原和闭环反应生成外消旋的4-硝基环氧苯乙烷,经手性(R,R)-Salen-Co(Ⅲ)催化剂催化水解动力学拆分(HKR)得到(R)-4-硝基环氧苯乙酮和(S)-1-(4-硝基苯基)-1,2-乙二醇。环氧中间体经异丙胺作用生成(R)-硝苯洛尔,所得到的二醇先与氯化亚砜作用生成环状亚硫酸酯,再与异丙胺反应得到(S)-硝苯洛尔。产物结构经1HNMR、IR、MS表征。 Using 4-nitroacetophenone as starting material, racemic 4-nitroxyphenyl ethane was formed by bromination, reduction and ring-closing reaction, which was catalyzed by chiral (R, R) -Salen-Co Hydrolysis kinetic resolution (HKR) yielded (R) -4-nitroxyphenylacetophenone and (S) -1- (4-nitrophenyl) -1,2-ethanediol. (R) -nitrobenzol is produced through the isopropylamine reaction of the epoxy intermediate. The resulting diol first interacts with thionyl chloride to form a cyclic sulfite, which is then reacted with isopropylamine to give (S) -nitrilol Seoul The product structure was characterized by 1HNMR, IR and MS.