通过对盐单胞菌（Halomonassp．）C6的抗性研究，发现该菌对3种氨基糖甙类抗生素（卡那霉素、新霉素的庆大霉素）的抗性反应受渗透压调节。在低盐浓度条件下，C6对这些抗生素敏感，但在高盐浓度下，该菌能抗一定浓度的这类抗生素。C6的细胞含有质粒pWH1，转化大肠杆菌（Ecoli）DH(5α)后得到3种对上述抗生素有不同反应的转化子，表明C6对这3种抗生素的抗性是由该质粒决定的。 By studying the resistance of Halomonassp. C6, the resistance of the strain to three aminoglycoside antibiotics (kanamycin, neomycin, gentamicin) was found to be regulated by osmotic pressure . At low salt concentrations, C6 is sensitive to these antibiotics, but at high salt concentrations, the bacteria are able to resist such concentrations of antibiotics. C6 cells contained the plasmid pWH1 and transformed into Ecoli DH (5α). Three transformants different in response to the above antibiotics were obtained, indicating that the resistance of C6 to the three antibiotics is determined by the plasmid.