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目的 :了解原发性肝癌患者经肝动脉化疗栓塞术 (TACE)后免疫功能状态。方法 :我们应用流式细胞仪检测了 16例原发性肝癌患者TACE术前后T细胞表面抗原标志 (CD3、CD4、CD8) ,并与良性病变患者进行对比分析。结果 :原发性肝癌患者术前CD3 +、CD4+、CD4+/CD8+均低于对照组 ,CD8+高于对照组 ,TACE术后CD8+降低 ,CD3 +、CD4+、CD4+/CD8+均升高。结论 :原发性肝癌患者治疗前免疫功能低下 ,术后活化T细胞增多 ,TACE术可减少肿瘤负荷 ,提高机体免疫反应。
Objective : To understand the immune status of patients with primary liver cancer after transcatheter arterial chemoembolization (TACE). METHODS: We used flow cytometry to detect T cell surface antigen markers (CD3, CD4, CD8) before and after TACE in 16 patients with primary liver cancer, and compared them with benign lesions. Results: Preoperative CD3 +, CD4 +, CD4 + / CD8 + were lower in patients with primary liver cancer than in the control group. CD8 + was higher than that in the control group. CD8 + was decreased after TACE, and CD3 +, CD4 +, and CD4 +/CD8 + were all increased. Conclusion: The pre-treatment immune function of patients with primary liver cancer is low and the number of activated T cells increases after surgery. TACE can reduce the tumor burden and improve the immune response.