Expression of telomerase gene hTERT in testis of infertile male and its significance

来源 :Asian Journal of Andrology | 被引量 : 0次 | 上传用户:yuqiang521
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Objective: To study the expression and the significance of telomerase gene hTERT in testes of infertile males. Methods: By using the in situ hybridization (ISH) technique, the expression of telomerase gene hTERT mRNA in testes of 47 infertile males and 10 normal men were observed. Results: In the testes, there was a positive correlation between the expression of hTERT and the density of germ cells (spermatogonia, spermatocyte and spermatid). The expression of hTERT in certain germ cells in maturation arrest patients was not significantly different from those of the normal controls. Conclusion: Deficiency of telomerase might be an etiological factor of germ cell maturation arrest. Our study provides experimental groundwork for the gene therapy of male infertility Objective: To study the expression and the significance of telomerase gene hTERT in testes of infertile males. Methods: By using the in situ hybridization (ISH) technique, the expression of telomerase gene hTERT mRNA in testes of 47 infertile males and 10 Results: In the testes, there was a positive correlation between the expression of hTERT and the density of germ cells (spermatogonia, spermatocyte and spermatid). The expression of hTERT in certain germ cells in maturation arrest patients was not significantly different from those of the normal controls. Conclusion: Deficiency of telomerase might be an etiological factor of germ cell maturation arrest. Our study provides experimental groundwork for the gene therapy of male infertility
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