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黏膜相关淋巴组织(MALT)淋巴瘤是非霍奇金淋巴瘤中结外边缘带淋巴瘤(MZL)的一种特殊类型。眼附属器MALT淋巴瘤是眼眶恶性肿瘤中较常见的一种,可发生在结膜、泪腺、眼睑和眼眶。近年来,国外许多学者在MALT淋巴瘤的临床特点、病理形态学、免疫表型、分子遗传学及分子生物学方面对它的发生机制在基因水平有了新的认识。就国外对眼附属器MALT淋巴瘤的分子遗传学异常在肿瘤细胞内部信号转导通路中作用的研究做一综述。
Mucosal-associated lymphoid tissue (MALT) lymphoma is a special type of extranodal marginal lymphoma (MZL) in non-Hodgkin’s lymphoma. Ocular appendage MALT lymphoma is a more common type of orbital malignancy that can occur in the conjunctiva, lacrimal gland, eyelid, and orbit. In recent years, many foreign scholars have got a new understanding of the genesis mechanism of MALT lymphoma in its clinical features, pathomorphology, immunophenotype, molecular genetics and molecular biology. This review summarizes the role of molecular abnormalities of ocular adnexal MALT lymphoma in the signal transduction pathway in tumor cells.