在全世界范围内,高血压都是造成过早死亡、可预防的最重要病因之一,抗高血压药物带来的益处在临床试验提供的最大量证据中得到验证。现有多类药物可供临床治疗,而对某些相关问题目前尚存有较大争议,例如:治疗的收益是否完全取决于血压控制的质量?应用的药物类型是否为一个影响结局的有力决定因素?这是关键的问题,因为“老”药(如噻嗪类 Hypertension is one of the most preventable causes of premature death worldwide, and the benefits of antihypertensive drugs are proven in the largest evidence of clinical trials. There are a number of existing types of medicines available for clinical treatment, and there are major controversies on some related issues, such as: Is the benefit of treatment solely dependent on the quality of blood pressure control? Is the type of drug being used a strong decision that affects outcomes Factors? This is the key issue, because “old” drugs (such as thiazides