【摘 要】
:
Ischemic stroke is a common and often devastating disease that primarily affects the elderly. Treatment currently consists predominantly of acute thrombolysis and/or thrombectomy to restore blood flow. This reperfusion therapy, however, is only accessible
【机 构】
:
Center for Perioperative Organ Protection,Department of Anesthesiology,Duke University Medical Cente
论文部分内容阅读
Ischemic stroke is a common and often devastating disease that primarily affects the elderly. Treatment currently consists predominantly of acute thrombolysis and/or thrombectomy to restore blood flow. This reperfusion therapy, however, is only accessible to a small fraction of stroke patients, and even among these patients, many still suffer life-long neurologic deficits. Thus, new stroke therapeutics are urgently needed to improve the quality of life for stroke patients.
其他文献
吉兰-巴雷综合征(Guillain-Barré syndrome,GBS)是一种自身免疫介导的多发性神经根神经病,可引起急性四肢弛缓性瘫痪和呼吸衰竭.临床治疗主要为静脉注射免疫球蛋白和血浆置换,虽然接受传统免疫治疗的大部分GBS患者预后良好,但是仍有约20%的患者预后较差,常遗留有不同程度后遗症.补体(complement,C)系统激活是GBS发病的关键环节,因此补体抑制剂有可能成为一种新的GBS治疗方案.目前部分补体抑制剂药物已被用于临床试验研究.本文就近年来补体抑制剂治疗GBS的研究进展进行综述.
The degeneration of nerve fibres following injury was first described by Augustus Waller over 170 years ago. Initially assumed to be a passive process, it is now evident that axons respond to insult via regulated cellular signaling events resulting in the
目的 研究癫痫大鼠海马和邻近颞叶皮层中分泌型酸性富含半胱氨酸样蛋白1型(secreted protein acidic and rich in cysteinel,SPARCL1)和整合素β1(Integrinβ1)的动态表达,以探讨二者对癫痫发展的影响.方法 将雄性SD大鼠56只随机分为对照组(21只)和致痫组(35只).致痫组予氯化锂(LiCl)匹罗卡品(PILO)进行造模,按癫痫发作后3 h、6 h、12 h、1 d、2 d、3 d、7 d时间点分为7个亚组,每亚组5只;对照组按对应时间分为7个亚组
Blood exosomes, which are extracellular vesicles secreted by living cells into the circulating blood, are regarded as a relatively noninvasive novel tool for monitoring brain physiology and disease states. An increasing number of blood cargo-loaded exosom
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor neurons. Most ALS cases are sporadic, but approximately 5–10% of patients have a familial background. To dat
DNA damage has been linked to neuropathology. Diverse DNA damage response (DDR) pathways help preserve DNA integrity in the nervous system during both the developmental and mature stages. Mutations of factors in various signaling pathways responsive to di
Neurovascular dysfunction, as an integral part of Alzheimer\'s disease, may have an important influence on the onset and progression of chronic neurodegenerative processes. The blood- brain barrier (BBB) pathway is one of the main pathways that mediates
The repair of injured tissue is a highly complex process that involves cell proliferation, differentiation, and migration. Cell migration requires the dismantling of intercellular contacts in the injured zone and their subsequent reconstitution in the wou
Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous system. Over the last few decades, a great deal of attention has been focused on white matter as a potent
Admission hyperglycemia is an independent predictor, that contributes to hemorrhagic transformation (HT), and worsened functional outcome following reperfusion therapy with tissue plasminogen activator (tPA) in ischemic stroke. Clinical studies have revea