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采用免疫组织化学SP法,对103例乳腺纤维腺瘤(FA)患者的乳腺肿物标本进行雌激素受体(ER)、孕激素受体(PR)检测,并收集患者的临床资料进行对比研究。发现ER阳性率为94.2%,PR阳性率为97.1%,ER、PR在不同年龄、生育哺乳史、肿瘤直径患者中的表达无统计学差异(P>0.05)。认为FA的ER、PR阳性率较高,ER、PR的表达与患者的年龄、生育哺乳史、肿瘤大小无明显相关性。对于ER和PR阳性的FA患者,术后进行及时、有效的内分泌治疗能降低其再发和多发的倾向。
Immunohistochemical SP method was used to detect estrogen receptor (ER) and progesterone receptor (PR) in 103 cases of breast fibroadenoma (FA) in patients with breast mass and to collect the clinical data of the patients for comparative study . The positive rate of ER was 94.2% and the positive rate of PR was 97.1%. There was no significant difference in the expression of ER and PR in patients with different ages, birth and breast-feeding history and tumor diameter (P> 0.05). It is considered that the positive rate of ER and PR in FA is high, the expression of ER and PR is not related to the patient’s age, birth and lactation history, tumor size. For ER and PR-positive FA patients, postoperative prompt and effective endocrine therapy can reduce its tendency to recurrence and multiple.