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目的通过研究Stomatin-like protein2(SLP-2)在宫颈腺癌中的表达,探讨SLP-2蛋白在宫颈腺癌发病中的作用。方法选择正常宫颈组11例,慢性宫颈炎组13例,宫颈腺癌组43例,应用免疫组化方法,研究SLP-2蛋白在宫颈腺癌组织内表达。结果 SLP-2蛋白定位于宫颈上皮细胞胞质内。宫颈腺癌组织,慢性宫颈炎组织及正常宫颈组织中SLP-2蛋白的阳性表达率分别为69.8%、15.4%和零,其中宫颈腺癌与正常宫颈组织间SLP-2蛋白阳性表达率差异有统计学意义(P<0.01),与慢性宫颈炎相比,SLP-2蛋白阳性表达率差异有统计学意义(P<0.01),而正常宫颈和慢性宫颈炎组织间SLP-2蛋白阳性表达率差异无统计学意义(P>0.05)。结论①SLP-2蛋白在宫颈腺癌中的表达明显高于正常和慢性宫颈炎的人。②SLP-2蛋白在肿瘤的发生和发展中起重要的作用,参与了宫颈腺癌的形成机制,并且将成为宫颈癌早期筛查和诊断的有力工具和治疗的新靶点。
Objective To investigate the role of SLP-2 in the pathogenesis of cervical adenocarcinoma by studying the expression of Stomatin-like protein2 (SLP-2) in cervical adenocarcinoma. Methods 11 cases of normal cervical group, 13 cases of chronic cervicitis group and 43 cases of cervical adenocarcinoma group were selected. The expression of SLP-2 protein in cervical adenocarcinoma was studied by immunohistochemistry. Results SLP-2 protein localized in the cytoplasm of cervical epithelial cells. The positive rates of SLP-2 protein expression in cervical adenocarcinoma, chronic cervicitis and normal cervical tissues were 69.8%, 15.4% and 0 respectively. The positive rates of SLP-2 protein between cervical adenocarcinoma and normal cervical tissue were (P <0.01). Compared with chronic cervicitis, the positive expression rate of SLP-2 protein was significantly different (P <0.01), while the positive expression rate of SLP-2 protein between normal cervix and chronic cervicitis The difference was not statistically significant (P> 0.05). Conclusion ① The expression of SLP-2 protein in cervical adenocarcinoma was significantly higher than that in normal and chronic cervicitis. ② The expression of SLP-2 protein plays an important role in the carcinogenesis and progression of cancer and participates in the formation of cervical adenocarcinoma and will become a new target for early screening and diagnosis of cervical cancer.