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目的通过对尖锐湿疣(CA)患者皮损及外周血CD4+和CD8+细胞免疫功能检测的分析,探讨尖锐湿疣患者细胞免疫功能的变化及其对CA的影响。方法通过流式细胞仪(FCM)对40例CA患者及20名正常人外周血进行反映细胞免疫功能的T淋巴细胞亚群的检测,实验采用免疫组化的方法对40例CA皮损样本中CD4+和CD8+细胞的数目进行检测。结果CA患者外周血及皮损较正常对照组中的CD8+细胞百分率增加,CD4+细胞百分率及CD4+/CD8+比值降低。结论CA患者存在全身和局部的细胞免疫功能低下,而且局部皮损细胞免疫功能低下可能在CA的发病中具有重要作用。
Objective To investigate the changes of cellular immune function and its effect on CA in the patients with condyloma acuminatum (CA) by analyzing the immunological function of CD4 + and CD8 + cells in the lesions and peripheral blood of condyloma acuminatum (CA) patients. Methods The peripheral blood of 40 patients with CA and 20 normal controls were detected by flow cytometry (FCM). T lymphocyte subpopulations were detected by immunohistochemistry in 40 CA lesions The number of CD4 + and CD8 + cells was tested. Results The percentage of CD8 + cells and the percentage of CD4 + cells and CD4 + / CD8 + in peripheral blood and lesions in CA patients were significantly lower than those in normal controls. Conclusion There are systemic and local cellular immune dysfunction in CA patients, and the cellular immune dysfunction in local lesion may play an important role in the pathogenesis of CA.