论文部分内容阅读
目的探讨应用超谐波声学造影和声学密度定量(AD)技术,定量评价异体移植肾急性排异反应时皮质血流灌注的价值。方法建立犬异体移植肾急性排异模型,分别于术后第1、3、5、7、9、11d共6个时间点,采用经静脉声学造影和AD技术检查移植肾,测定肾皮质造影后峰值密度(PI)、曲线下面积(AUC)、降支减半时间(HT)及平均通过时间(MTT)等有关灌注参数,并同时进行穿刺活检。结果造影后发生急性排异反应的移植肾皮质灌注不良,出现充盈缺损区。移植肾术后5~11d,随着急性排异反应的逐渐加重,灌注参数PI、AUC、HT及MTT逐渐下降,50%清除斜率逐渐增加,与术后1d比较差异均有显著性意义(P<0.05)。结论超谐波声学造影结合AD技术,用于评价移植肾急性排异反应时皮质血流灌注是一安全、有效的方法,具有良好的应用前景。
Objective To investigate the value of quantitative evaluation of cortical blood flow perfusion in acute rejection of allogeneic renal allograft by using super-harmonic acoustic contrast and acoustic density quantitative (AD) technique. Methods The model of acute rejection of allogeneic renal allograft was established. At 6th, 5th, 7th, 7th and 11th day postoperatively, allograft kidneys were examined by transthoracic echocardiography and AD. Peak perfusion density (PI), area under the curve (AUC), hypotection half-time (HT) and mean transit time (MTT) were measured and perfusion biopsy was performed simultaneously. ResultsAcute rejection after angiography of renal graft cortical dysplasia, filling defect area. At 5 to 11 days after transplantation, the perfusion parameters PI, AUC, HT and MTT decreased gradually with the gradual increase of acute rejection, and the slope of 50% clearance increased gradually, which was significantly different from that at 1 day <0.05). Conclusion The combination of hypersound acoustography and AD technique is a safe and effective method for evaluating cortical perfusion in acute rejection of renal allograft and has a good prospect of application.