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目的探讨内皮素 -1(ET-1)和一氧化氮 (NO)在老年肺癌患者血清和肿瘤组织中的水平及临床意义。方法应用比色法和放免法测定 40例老年肺癌患者血清和组织中的内皮素 -1和一氧化氮的含量 ,并设 3 0例正常人和 2 0例肺良性病变患者为对照组。结果肺癌组织中 NO和 ET-1含量显著高于癌旁组织 (P<0 .0 1) ,也高于良性病变组 (P<0 .0 1) ;肺癌患者血清 ET-1的含量高于正常和良性病变组 (P<0 .0 1) ,而 NO含量则低于正常和良性病变组 (P<0 .0 1)。但各细胞学类型之间血清和组织的 ET-1和 NO含量无差异。结论ET-1和 NO可能参与了肺癌的发生与发展 ,有望成为肺癌进展期的临床检验指标
Objective To investigate the levels and clinical significance of endothelin-1 (ET-1) and nitric oxide (NO) in serum and tumor tissues of elderly patients with lung cancer. Methods Colorimetric and radioimmunoassay methods were used to determine the serum and tissue levels of endothelin-1 and nitric oxide in 40 elderly patients with lung cancer. Thirty patients with normal controls and 20 patients with benign pulmonary lesions were used as controls. Results The contents of NO and ET-1 in lung cancer tissues were significantly higher than those in adjacent tissues (P<0.01) and also higher in benign lesions (P<0.01). The levels of serum ET-1 were higher in lung cancer patients. In normal and benign lesions (P < 0.01), NO levels were lower than those in normal and benign lesions (P <0.01). However, serum and tissue ET-1 and NO levels did not differ between cytological types. Conclusion ET-1 and NO may be involved in the occurrence and development of lung cancer, and it is expected to become a clinical test index of advanced lung cancer.