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目的 :观察和比较 3%膦甲酸钠和 0 1%无环鸟苷滴眼液治疗单纯疱疹性角膜炎的疗效和安全性。方法 :对门诊16 4例单纯疱疹性角膜炎病人进行多中心、双盲、平行组对照和开放试验等方法进行检查治疗。结果 :膦甲酸钠组治愈率为6 5 0 0 % ,有效率为 85 0 0 % ;无环鸟苷组分别为 41 2 7% ,6 9 84% ;开放组分别为 43 90 %和 75 6 1%。经统计学分析 :治愈率有统计学显著性 (P =0 0 1) ,有效率有显著性 (P =0 0 5 ) ,膦甲酸钠滴眼液疗效优于无环鸟苷滴眼液 ,并未发现全身性毒副作用 ,仅有轻微一过性眼部刺激 ,其发生率与对照组相似。结论 :膦甲酸钠滴眼液疗效较无环鸟苷滴眼液佳 ,且使用安全。
Objective: To observe and compare the efficacy and safety of 3% foscarnet and 0.1% acyclovir eye drops in the treatment of herpes simplex keratitis. Methods: 16 4 outpatients with herpes simplex keratitis were examined by multi-center, double-blind, parallel group control and open trial methods. Results: The cure rate of foscarnet group was 6500%, the effective rate was 85%, that of acyclovir group was 41 2 7% and 69 84% respectively, that of open group was 43 90% and 75 6 1 respectively %. The statistical analysis: the cure rate was statistically significant (P = 0 0 1), effective rate was significant (P = 0 05), foscarnet eye drops efficacy is superior to acyclovir eye drops and No systemic side effects were observed, only a slight transient eye irritation, the incidence was similar to the control group. Conclusion: The efficacy of foscarnet eye drops is better than acyclovir eye drops and safe to use.