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目的：探讨微量元素硒（Ｓｅ）、锌（Ｚｎ）、铜（Ｃｕ）、铁（Ｆｅ）在妇科肿瘤发生中的作用。方法：使用原子吸收分光光度计及ＸＤＹ－Ⅰ型原子荧光光度法检测１６４例妇科恶性肿瘤、５３例良性肿瘤和２５例非肿瘤者头发中Ｓｅ、Ｚｎ、Ｃｕ、Ｆｅ４种微量元素含量。结果：①妇科恶性肿瘤患者头发中Ｓｅ、Ｚｎ含量明显低于良性肿瘤和非肿瘤者（Ｐ＜０．００１）；Ｃｕ、Ｆｅ含量明显增高与良性肿瘤和非肿瘤者差异有显著性（Ｐ＜０．００１）。②子宫颈癌、子宫内膜癌随临床期别的增高，Ｓｅ、Ｚｎ含量逐渐降低，Ｃｕ含量逐渐升高，但Ｆｅ与肿瘤患者的临床期别无明显关系。结论：头发中４种微量元素的变化对妇科恶性肿瘤的早期诊断和防、治具有一定的临床意义。
Objective: To investigate the role of trace elements Se, Zn, Cu and Fe in gynecologic oncology. Methods: The contents of trace elements Se, Zn, Cu and Fe in 164 cases of gynecological malignant tumor, 53 benign tumor and 25 non-tumor hair were detected by atomic absorption spectrophotometer and XDY-Ⅰ atomic fluorescence spectrometry. Results: ① The contents of Se and Zn in the hair of gynecological malignant tumor patients were significantly lower than those of benign and non-tumorous patients (P <0.001). The contents of Cu and Fe were significantly higher than those of benign and non-neoplastic patients (P < 0.001). (2) The contents of Se and Zn in cervical cancer and endometrial cancer increased gradually with the clinical stage, while the content of Cu increased gradually. However, there was no significant relationship between the Fe and the clinical stage of cancer patients. Conclusion: The changes of four trace elements in hair have certain clinical significance for the early diagnosis, prevention and treatment of gynecologic malignancies.