本文报导,从放线菌 Streptomyces galilaeus的发酵液中分离到一种新的蒽环类抗肿瘤抗菌素Aclacinomycins A 和 B。该菌株在1%葡萄糖,1%马铃薯粉,1.5%黄豆粉,0.1%KH_2PO_4,0.1%MgSO_4·7H_2O,0.3%NaCl,0.007%CuSO_4·5H_2O,0.0001%FeSO_4·7H_O,0.0008%MnCl_2·4H_2O 和0.0002%ZnSO_4·7H_2O,pH7.0的培养基中于28°振荡培养4天后,调节至 pH4.5,过滤,菌丝用丙酮提取,滤液于 pH6.8以乙酸乙酯提取,真空浓缩后 This paper reports the isolation of a new anthracycline antitumor antibacterial Aclacinomycins A and B from the fermentation broth of actinomycetes Streptomyces galilaeus. The strain was cultured in 1% glucose, 1% potato flour, 1.5% soybean flour, 0.1% KH 2 PO 4, 0.1% MgSO 4 · 7H 2 O, 0.3% NaCl, 0.007% CuSO 4 · 5H 2 O, 0.0001% FeSO 4 · 7H_O, 0.0008% MnCl 2 · 4H 2 O and 0.0002 % ZnSO 4 · 7H 2 O and pH 7.0 for 4 days at 28 ° C. After shaking for 4 days, the mixture was adjusted to pH 4.5, filtered, mycelium was extracted with acetone, the filtrate was extracted with ethyl acetate at pH 6.8 and concentrated in vacuo